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Daniel Barker...
Posted: Fri Nov 13, 2009 10:25 pm
We are seeking applicants for a PhD position at the University of St
Andrews, Scotland.


Dr Daniel Barker, University of St Andrews, and Professor Geoffrey Codd,
University of Dundee.

This project will improve knowledge of the evolution, metabolism,
ecotoxicological status and biotechnological potential of cyanobacteria
by the development and application of bioinformatics algorithms.
Cyanobacteria are a metabolically diverse group of photosynthetic
prokaryotes of global distribution. They play a crucial role in
biogeochemical cycles (oxygen, carbon, nitrogen), produce toxins which
present major health hazards to humans and animals, yet also contain
metabolites with therapeutic and biotechnological applications,
including biofuels. At least 48 cyanobacterial genomes have been
sequenced. However, the function of many of the genes in their genomes
remains unknown. This represents a major gap in biological knowledge
which would be difficult to fill by traditional approaches. We have
developed a comparative, bioinformatics procedure to delimit groups of
genes which are functionally linked, on the basis of correlated gain and
loss of those genes from genomes. This must be vastly improved, to also
model gene-phenotype and gene-environment interactions, and applied to
cyanobacteria. The project would involve research in computational
comparative genomics. Results will be of interest to researchers in
bioinformatics, environmental and health sciences and in biotechnology.

Informal enquiries to Daniel Barker, db60 at (no spam)

For further details, including how to apply, please see:


A successful candidate would receive funding (covering fees and stipend)
from the Natural Environment Research Council (NERC) and Marine Alliance
for Science & Technology Scotland. Funding is ONLY possible for
candiates who meet NERC's criteria:

In particular, please note the section "Residence" (pp. 3-6). If you do
not meet these criteria, please only apply for this position if you have
already obtained funding yourself.

Daniel Barker
The University of St Andrews is a charity registered in Scotland :
No SC013532
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